Colorectal Cancer in Young Adults: New Genetic Hypotheses Emerge from IARC Research
A study by IARC published on 7 July 2025 analyzed over 1,100 cases of colorectal cancer, highlighting specific genetic mutations more common in patients under the age of 40. Some of these mutations are linked to the presence of particular gut bacteria, suggesting a direct role of the microbiome in the early onset of cancer.
The mutational signatures observed differ from those in older patients, opening new diagnostic hypotheses. The study emphasizes the opportunity to develop personalized screening pathways and more sensitive molecular tests for young individuals, who are often excluded from standard prevention programs.
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The general objective of EUCanScreen is to assure sustainable implementation of high-quality screening for breast, cervical and colorectal cancers, as well as implementation of the recently recommended screening programs – for lung, prostate and gastric cancers. EUCanScreen will facilitate the reduction of cancer burden and achieving equity across the EU.
This project has received funding from the European Union’s EU4HEALTH Programme under the Grant Agreement no 101162959